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. 1997 Jan 20;8(2):497-500.
doi: 10.1097/00001756-199701200-00024.

Involvement of endogenous orphanin FQ in electroacupuncture-induced analgesia

J H Tian  1 , W Xu, W Zhang, Y Fang, J E Grisel, J S Mogil, D K Grandy, J S Han
Affiliations

Involvement of endogenous orphanin FQ in electroacupuncture-induced analgesia

J H Tian et al. Neuroreport. .

Abstract

Recent studies suggest that the novel opioid peptide orphanin FQ (OFQ) is involved in pain modulation. We found that intracerebroventricular (i.c.v.) administration of OFQ in the rat produced a dose-dependent antagonism of the analgesia induced by 100 Hz electroacupuncture (EA) stimulation as measured in the radiant heat tail-flick assay. Antisense oligonucleotides injected i.c.v. potentiated EA analgesia, presumably by interfering with the expression of the OFQ receptor in brain. These results suggest that endogenous OFQ exerts a tonic antagonistic effect on EA-induced analgesia. No such antagonism was observed when OFQ was injected intrathecally (i.t.). Rather, it appears that spinal OFQ produced a marked analgesic effect and enhanced EA-induced analgesia. These findings are consistent with the experimental results obtained in rats where morphine-induced analgesia is antagonized by i.c.v. OFQ and potentiated by i.t. OFQ.

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