Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1997 Mar;93(3):215-8.
doi: 10.1007/s004010050606.

Increased glutamine synthetase immunoreactivity in experimental pneumococcal meningitis

A K Stringaris  1 , W Brück, H Tumani, H Schmidt, R Nau
Affiliations

Increased glutamine synthetase immunoreactivity in experimental pneumococcal meningitis

A K Stringaris et al. Acta Neuropathol. 1997 Mar.

Abstract

Glutamine synthetase (GS), glial fibrillary acidic protein (GFAP) immunohistochemistry and neuronal apoptotic cell death were evaluated in a rabbit model of pneumococcal meningitis. Meningitis caused an increase of GS immunoreactivity in the cerebral cortex, but not in the hippocampal formation. GFAP immunoreactivity remained unchanged. This may represent a protective mechanism for cortical neurons. The inability of hippocampal GS to counteract the detrimental effects of glutamate may be the cause of neural apoptosis observed in the dentate gyrus during meningitis.

PubMed Disclaimer

Publication types

Substances

LinkOut - more resources