doi: 10.1007/BF01920177.
Metaraminol uptake by human thrombocytes: a poor model for neuronal noradrenaline uptake
- PMID: 908413
- DOI: 10.1007/BF01920177
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Metaraminol uptake by human thrombocytes: a poor model for neuronal noradrenaline uptake
Experientia.
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Abstract
The IC50 of a number of antidepressants and related drugs on the uptake of 1-metaraminol and serotonin into human thrombocytes, and of noradrenaline and serotonin into rat midbrain synaptosomes were compared. In accordance with previous reports, it was found that platelets provide a good model for the study of neuronal uptake of serotonin. Platelet uptake of 1-metaraminol, although correlated to some extent with noradrenaline uptake into synaptosomes, seems to be an unsatisfactory model for the neuronal uptake of the latter amine.
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