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. 1977 Oct 15;33(10):1354-5.
doi: 10.1007/BF01920177.

Metaraminol uptake by human thrombocytes: a poor model for neuronal noradrenaline uptake

P C Waldmeier, P A Baumann

Metaraminol uptake by human thrombocytes: a poor model for neuronal noradrenaline uptake

P C Waldmeier et al. Experientia. .

Abstract

The IC50 of a number of antidepressants and related drugs on the uptake of 1-metaraminol and serotonin into human thrombocytes, and of noradrenaline and serotonin into rat midbrain synaptosomes were compared. In accordance with previous reports, it was found that platelets provide a good model for the study of neuronal uptake of serotonin. Platelet uptake of 1-metaraminol, although correlated to some extent with noradrenaline uptake into synaptosomes, seems to be an unsatisfactory model for the neuronal uptake of the latter amine.

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