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. 1977 Aug;30(8):665-9.
doi: 10.7164/antibiotics.30.665.

Plasmid-mediated pristinamycin resistance. PAC IIA: a new enzyme which modifies pristinamycin IIA

F L Goffic, M L Capmau, D Bonnet, C Cerceau, C Soussy, A Dublanchet, J Duval
Free article

Plasmid-mediated pristinamycin resistance. PAC IIA: a new enzyme which modifies pristinamycin IIA

F L Goffic et al. J Antibiot (Tokyo). 1977 Aug.
Free article

Abstract

A wild strain of Staphylococcus aureus which inactivates a wide variety of antibiotics has been found to inactivate pristinamycin IIA, an antistaphylococcal antibiotic. This phenomenon has been demonstrated to be plasmid mediated. The plasmid directs the biosynthesis of an acetyltransferase which is able to O-acetylate the drug. We propose to call the new enzyme PAC (IIA): Pristinamycin acetyltransferase.

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