Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1997 Apr;41(4):863-5.
doi: 10.1128/AAC.41.4.863.

In vitro activity of a new semisynthetic echinocandin, LY-303366, against systemic isolates of Candida species, Cryptococcus neoformans, Blastomyces dermatitidis, and Aspergillus species

G G Zhanel  1 , J A Karlowsky, G A Harding, T V Balko, S A Zelenitsky, M Friesen, A Kabani, M Turik, D J Hoban
Affiliations
Comparative Study

In vitro activity of a new semisynthetic echinocandin, LY-303366, against systemic isolates of Candida species, Cryptococcus neoformans, Blastomyces dermatitidis, and Aspergillus species

G G Zhanel et al. Antimicrob Agents Chemother. 1997 Apr.

Abstract

The in vitro activities of LY-303366, a new semisynthetic echinocandin, and comparators amphotericin B, 5-fluorocytosine, fluconazole, and ketoconazole against 205 systemic isolates of Candida species, Cryptococcus neoformans, Blastomyces dermatitidis, and Aspergillus species were determined. LY-303366 had MICs of < or = 0.32 microg/ml for all Candida albicans (n = 99), Candida glabrata (n = 18), and Candida tropicalis (n = 10) isolates tested. LY-303366 was also active against Aspergillus species (minimum effective concentration at which 90% of the isolates are inhibited, 0.02 microg/ml) (n = 20), was less active against Candida parapsilosis (MIC at which 90% of the isolates are inhibited [MIC90], 5.12 microg/ml) (n = 10), and was inactive against C. neoformans (MIC90, >10.24 microg/ml) (n = 15) and B. dermatitidis (MIC90, 16 microg/ml) (n = 29).

PubMed Disclaimer

References

    1. Eur J Clin Microbiol Infect Dis. 1990 Sep;9(9):697-9 - PubMed
    1. Am J Med. 1991 Sep 16;91(3B):86S-89S - PubMed
    1. J Med Vet Mycol. 1994;32 Suppl 1:189-202 - PubMed
    1. Antimicrob Agents Chemother. 1994 Jul;38(7):1480-9 - PubMed
    1. Science. 1994 Apr 15;264(5157):371-3 - PubMed

Publication types