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Review
. 1997 Apr;7(2):273-8.
doi: 10.1016/s0959-440x(97)80036-x.

The proteasome

W Baumeister  1 , A Lupas
Affiliations
Review

The proteasome

W Baumeister et al. Curr Opin Struct Biol. 1997 Apr.

Abstract

The proteasome is a macromolecular assembly that is designed to confine proteolytic activity to an inner cavity. Access to the central proteolytic nanocompartment is restricted to unfolded proteins, which necessitates a functional coupling of the 20S proteasome to a substrate-recognition and unfolding machinery. Significant progress has been made during the past two years in elucidating the structural principles and the enzymatic mechanism of the 20S proteasome.

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