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. 1997 Apr 1;94(7):2787-8.
doi: 10.1073/pnas.94.7.2787.

Imaging the living human brain: magnetic resonance imaging and positron emission tomography

N D Volkow  1 , B Rosen, L Farde
Affiliations

Imaging the living human brain: magnetic resonance imaging and positron emission tomography

N D Volkow et al. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
fMRI activation images obtained with a visually guided generation task. The leftmost figure shows a horizontal section of an activation map. Areas of increased activation (BOLD contrast) are shown in brighter colors overlaid on top of a T2* weighted image. Robust activations are seen in visual cortex and in left prefrontal cortex. The image second to the left shows a region (in yellow) that was defined around significantly activated voxels in left prefrontal cortex. The next image shows the time course of this region’s activity during periods where multiple trials of the word-generation task were performed during 30-sec blocks (placement of blocks shown in red). Note the consistent and sustained signal increase that occurs shortly after the onset of the word-generation task. The rightmost image shows what happens in the same left prefrontal region when the time course is examined during a different paradigm involving separated individual trials of the task. Within such a paradigm, a small but reliable signal increase was observed in relation to the onset of individual trials of the task (placement of the averaged 1.5-sec trial shown in red). Courtesy of Massachusetts General Hospital.
Figure 2
Figure 2
Diagram of the dopamine (DA) synapse along with the PET images for different molecular targets: DA D2 receptors are imaged with [11C]raclopride, DA transporters are imaged with d-threo-[11C]methylphenidate, monoamine oxidase A is imaged with [11C]clorgyline, and monoamine oxidase B (located in glial cells) is imaged with deuterium-substituted [11C]deprenyl. Courtesy of Brookhaven National Laboratory.
See this image and copyright information in PMC

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