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. 1997 Feb 21;762(1-2):219-25.
doi: 10.1016/s0021-9673(96)00852-7.

Refractive-index detection by interferometric backscatter in packed-capillary high-performance liquid chromatography

C K Kenmore  1 , S R Erskine, D J Bornhop
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Refractive-index detection by interferometric backscatter in packed-capillary high-performance liquid chromatography

C K Kenmore et al. J Chromatogr A. .

Abstract

A simple, inexpensive, micro-volume refractive index detector has been applied to packed capillary high-performance liquid chromatography. Nanoliter detector volumes produced by a unique optical train, based on interferometric backscatter, allows for universal solute detection at the picogram level. System utility is demonstrated by reversed-phase separation of a test mixture containing ppm levels of NaCl, phenol, ethyl benzene and toluene.

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