Review
doi: 10.1016/s0952-7915(97)80146-x.
Early alpha beta T cell development in the thymus of normal and genetically altered mice
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- PMID: 9099797
- DOI: 10.1016/s0952-7915(97)80146-x
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Review
Early alpha beta T cell development in the thymus of normal and genetically altered mice
Curr Opin Immunol.
1997 Apr.
Abstract
The vast majority of T lymphocytes, with the exception of gut-associated, intraepithelial lymphocytes, differentiate and mature inside the thymus. Early T cell development is characterized by expansion and differentiation of thymocytes which do not yet express mature TCRs on their cell surface. Important events in early thymocyte development are controlled by a pre-TCR complex consisting of a conventional TCR beta chain and a novel transmembrane protein termed pre-TCR alpha (p T alpha chain) which are noncovalently associated with components of CD3. Recent studies of pre-TCR function have led to a better understanding of the molecular events in early thymocyte development.
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