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. 1977 Nov 18;198(4318):743-4.
doi: 10.1126/science.910158.

13-cis-Retinoic acid: inhibition of bladder carcinogenesis induced in rats by N-butyl-N-(4-hydroxybutyl)nitrosamine

C J Grubbs, R C Moon, R A Squire, G M Farrow, S F Stinson, D G Goodman, C C Brown, M B Sporn

13-cis-Retinoic acid: inhibition of bladder carcinogenesis induced in rats by N-butyl-N-(4-hydroxybutyl)nitrosamine

C J Grubbs et al. Science. .

Abstract

Transitional cell carcinoma was induced in the bladders of male Fischer rats by 12 oral doses of the carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine. Feeding of 13-cis-retinoic acid after completion of carcinogen treatment diminished the number and severity of cancers and other proliferative lesions of the bladder.

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