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. 1997 Mar;2(2):133-6.
doi: 10.1038/sj.mp.4000227.

Production of cytokines following brain injury: beneficial and deleterious for the damaged tissue

M C Morganti-Kossman  1 , P M Lenzlinger, V Hans, P Stahel, E Csuka, E Ammann, R Stocker, O Trentz, T Kossmann
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Production of cytokines following brain injury: beneficial and deleterious for the damaged tissue

M C Morganti-Kossman et al. Mol Psychiatry. 1997 Mar.

Abstract

A profound inflammatory response is initiated immediately following traumatic brain injury (TBI) and is characterized by the release of several cytokines with pro- and anti-inflammatory functions. In order to elucidate which cytokines are released in the human brain in response to injury as well as in the peripheral compartment, IL-1, IL-6, IL-8, IL-10, TNF-alpha and TGF-beta were monitored in CSF and serum of severely brain-injured patients. Furthermore, we investigated the possible modulation of systemic reactions by IL-6 and the ability of IL-6 and IL-8 to promote the synthesis of nerve growth factor.

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