Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1977;18(3):349-60.
doi: 10.1186/BF03548432.

Saponin adjuvants. IV. Evaluation of the adjuvant quil A in the vaccination of cattle against foot-and-mouth disease

K Dalsgaard, M H Jensen, K J Sorensen

Saponin adjuvants. IV. Evaluation of the adjuvant quil A in the vaccination of cattle against foot-and-mouth disease

K Dalsgaard et al. Acta Vet Scand. 1977.

Abstract

The saponin adjuvant Quil A has been investigated in the vaccination of cattle against foot-and-mouth disease. Using a Frenkel type vaccine a dose-response relationship has been established between Quil A and neutralizing antibody titres. Ten ml of vaccine was combined with 0, 50, 200, 800, and 3200 µg of Quil A. The combinations were each injected into 4 animals. The local reaction on the site of injection produced by injection of the vaccine alone and in combination with different doses of Quil A has been estimated. On this basis a therapeutical dose at 1 mg of Quil A has been estimated to combine maximum adjuvant effect with a minimum of adverse reactions. This dose has been tested in the vaccination of cattle with FMD vaccines derived from BHK suspension cell virus of type O and A respectively. The vaccines were tested in 10 ml and 5 ml doses with or without Quil A, and each in 4 animals. It is concluded that Quil A is a valuable adjuvant for use in the induction of neutralizing antibodies against foot-and-mouth disease in cattle.

PubMed Disclaimer

References

    1. Anderson E C, Masters R C, Mowat G N. Immune response of pigs to inactivated foot-and-mouth disease vaccines. Res. vet. Sci. 1971;12:351–357. doi: 10.1016/S0034-5288(18)34162-6. - DOI - PubMed
    1. Bayramoglu O, Unluleblebici N, Girard H C. Duree de 1’immunite consecutive a I’utilisation du vaccin antiaphteux prepare avec 10 et 25 milligrammes de saponine par dose. (Duration of the immunity after application of a foot-and-mouth disease vaccine prepared with 10 or 25 mg of saponin per dose). Bull. Acad, vet. Fr. 1968;41:165–168. - PubMed
    1. Charlier G, Strobbe R, Debecq J, Lennen J. Studies about the adjuvant activity of saponin fractions in foot-and-mouth disease vaccines. Arch. exp. Vet.-Med. 1973;27:783–789. - PubMed
    1. Croxton F E. Elementary Statistics, with Applications in Medicine and the Biological Sciences. New York: Dover Publications Inc.; 1959.
    1. Dalsgaard K. Thin-layer chromatographic fingerprinting of commercially available saponins. Dansk T. Farm. 1970;44:327–331. - PubMed

MeSH terms

LinkOut - more resources