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Case Reports
. 1997 Apr;130(4):551-6.
doi: 10.1016/s0022-3476(97)70238-5.

Infantile-onset multisystem inflammatory disease: a differential diagnosis of systemic juvenile rheumatoid arthritis

C L De Cunto  1 , D I Liberatore, J L San Román, J C Goldberg, A A Morandi, G Feldman
Affiliations
Case Reports

Infantile-onset multisystem inflammatory disease: a differential diagnosis of systemic juvenile rheumatoid arthritis

C L De Cunto et al. J Pediatr. 1997 Apr.

Abstract

We describe four unrelated children with neonatal maculopapular rash, fever, arthritis, hepatosplenomegaly, lymphadenopathy, eye involvement, and neurologic symptoms. Radiographs of the joints were surprisingly similar, showing an abnormal epiphyseal and metaphyseal appearance. These clinical and radiologic findings allowed us to include these children in a very peculiar syndrome described as infantile-onset multisystemic inflammatory disease. A chondrosarcoma developed in one of our patients.

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