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. 1997 Feb;14(2):289-95.
doi: 10.1023/a:1018510309524.

Influence of transferrin glycans on receptor binding and iron-donation

P Hoefkens  1 , M I Huijskes-Heins, C M de Jeu-Jaspars, W L van Noort, H G van Eijk
Affiliations

Influence of transferrin glycans on receptor binding and iron-donation

P Hoefkens et al. Glycoconj J. 1997 Feb.

Abstract

Human bi-bi-antennary transferrin (Tf) was partially deglycosylated by subsequently incubating with one or more of the following exoglycosidases: neuraminidase, beta-galactosidase or N-Acetyl-beta-D-glucosaminidase. Aglyco-Tf obtained from serum of a patient suffering from the Carbohydrate Deficient Glycoprotein syndrome was isolated. Receptor binding and the Tf and iron uptake capacities of the fully glycosylated-, partially deglycosylated- and aglyco-Tf were compared using the human hepatoma cell line PLC/PRF/5. No difference in binding capacity between the iso-Tf fractions could be demonstrated, however, the Tf and iron uptake capacity of aglyco-Tf was clearly reduced compared with the other Tf fractions.

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