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. 1997 Apr;244(4):262-5.
doi: 10.1007/s004150050082.

Mitochondrial DNA polymorphisms in pathologically proven Parkinson's disease

O Bandmann  1 , M G Sweeney, S E Daniel, C D Marsden, N W Wood
Affiliations

Mitochondrial DNA polymorphisms in pathologically proven Parkinson's disease

O Bandmann et al. J Neurol. 1997 Apr.

Abstract

To date, five single base pair changes of the mitochondrial DNA have been reported to occur either exclusively or with increased frequency in Caucasian patients with Parkinson's disease (PD) and it has been postulated that these mutations might be casually related to the observed inhibition of mitochondrial respiratory chain function in PD. To evaluate these findings, we analysed the frequency of all five polymorphisms in 100 cases of pathologically proven cases of PD. We were either unable to detect the previously described polymorphisms in our series or found them to be present with the same frequency among controls. Our data do not support the hypothesis of an involvement of the mitochondrial DNA in the pathogenesis of PD.

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References

    1. J Neurol Neurosurg Psychiatry. 1992 Mar;55(3):181-4 - PubMed
    1. Neurology. 1996 May;46(5):1275-84 - PubMed
    1. Q J Med. 1993 Oct;86(10):657-60 - PubMed
    1. Biochem Biophys Res Commun. 1991 Apr 30;176(2):938-46 - PubMed
    1. Mov Disord. 1990;5(2):109-17 - PubMed

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