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. 1997 Jan-Feb;330(1-2):12-6.
doi: 10.1002/ardp.19973300104.

Antimalarial activity of 1,4-epidioxy-bisabola-2,12-diene derivatives

G Rücker  1 , E Breitmaier, D Manns, W Maier, A Marek, B Heinzmann, K Heiden, S Seggewies
Affiliations

Antimalarial activity of 1,4-epidioxy-bisabola-2,12-diene derivatives

G Rücker et al. Arch Pharm (Weinheim). 1997 Jan-Feb.

Abstract

1,4-Epidioxy-bisabola-2,12-diene (3) and aromatic hydroperoxides (4, 5) were prepared by photoxidation of gamma-curcumene (1). Reduction and esterification of 6 and 7 afforded compounds 9 to 10. All compounds were tested in vitro for antimalarial activity. The activity could not be increased significantly, compared with 3. The most active compounds, 3 and 9, did not show in vivo antimalarial activity in mice.

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