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. 1977 Oct;4(5):513-7.
doi: 10.1111/j.1365-2125.1977.tb00778.x.

Cardiovascular effects of a new inotropic agent, U. K. 14275, in patients with coronary heart disease

I Hutton, W S Hillis, C E Langhan, J M Conely, T D Lawrie

Cardiovascular effects of a new inotropic agent, U. K. 14275, in patients with coronary heart disease

I Hutton et al. Br J Clin Pharmacol. 1977 Oct.

Abstract

1 The chronotropic and inotropic properties of U.K. 14275, a phosphodiesterase inhibitor were assessed in patients with coronary heart disease. 2 Left ventricular function was assessed in eight patients with acute myocardial infarction using the non-invasive measurement of systolic time intervals. 3 Twelve patients with angina pectoris were studied during diagnostic coronary arteriography. Left ventricular function was assessed using a high fidelity catheter tipped transducer in the left ventricle. 4 In both groups of patients U.K. 14275 infused intravenously in doses of 32, 64, 128 and 256 microgram kg-1 bodyweight min-1 enhanced the contractile state of the left ventricle without altering the heart rate.

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References

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