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Comparative Study
. 1977;4Suppl 2(Suppl 2):117S-121S.
doi: 10.1111/j.1365-2125.1977.tb05737.x.

A simple gas chromatographic method for the determination of nomifensine in plasma and a comparison of the method with other available techniques

J Chamberlain, H M Hill
Comparative Study

A simple gas chromatographic method for the determination of nomifensine in plasma and a comparison of the method with other available techniques

J Chamberlain et al. Br J Clin Pharmacol. 1977.

Abstract

1. A rapid simple gas chromatographic technique for determining nomifensine in plasma is described. 2. Nomifensine is rapidly absorbed after oral administration to man. 3. Following a 100-mg dose, peak levels of an acid-labile conjugate of 2--3 microgram/ml are reached about 1.5 h after administration. 4. The conjugate is cleared with a half-life of between 1 and 2 hours.

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References

    1. J Chromatogr. 1977 Jan 21;131:347-55 - PubMed
    1. J Chromatogr. 1976 Jan 21;116(2):451-6 - PubMed

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