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. 1979 Jul;76(7):3460-3.
doi: 10.1073/pnas.76.7.3460.

Antigenic marker on a functional subpopulation of B cells, controlled by the I-A subregion of the H-2 complex

B T Huber

Antigenic marker on a functional subpopulation of B cells, controlled by the I-A subregion of the H-2 complex

B T Huber. Proc Natl Acad Sci U S A. 1979 Jul.

Abstract

CBA/N mice have an X-linked recessive effect that results in the absence of a subpopulation of B cells carrying the Lyb3 surface marker. It has been shown previously that this marker is present on a mature subset of B cells in all mouse strains. In this paper the Lyb3+ B cell population in C57BL/6 mice was analyzed further. This subset of B cells selectively expresses a surface marker controlled by the I-A subregion of the H-2 complex. A cytotoxic antiserum recognizing this marker was raised by immunizing defective (CBA/N X C57BL/6)F1 male mice with C57BL/6 spleen cells. This antiserum also contained noncytotoxic, non-strain-restricted anti-Lyb3 antibodies. The possible functional relevance of this surface marker is discussed.

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