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. 1977;4Suppl 2(Suppl 2):159S-163S.
doi: 10.1111/j.1365-2125.1977.tb05745.x.

Effects of nomifensine in vitro on uptake of 5-hydroxytryptamine and dopamine into human platelets

R S Ehsanullah, P Turner

Effects of nomifensine in vitro on uptake of 5-hydroxytryptamine and dopamine into human platelets

R S Ehsanullah et al. Br J Clin Pharmacol. 1977.

Abstract

1. The effect of nomifensine on the uptake of 5-hydroxytryptamine (5-HT) and dopamine (DA) into human platelet-rich plasma has been studied. 2. A significant inhibition of DA uptake was observed at nomifensine 10(-6) M. 3. 5-HT uptake was significantly inhibited only at nomifensine 10(-4) M or more. 4. These results are consistent with those from previous animal experiments and suggest that the human platelet may be used as a model for studying DA uptake as well as that of 5-HT.

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