Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1997 Mar 10;404(2-3):294-8.
doi: 10.1016/s0014-5793(97)00128-2.

Desensitization of the P2X(2) receptor controlled by alternative splicing

U Brändle  1 , P Spielmanns, R Osteroth, J Sim, A Surprenant, G Buell, J P Ruppersberg, P K Plinkert, H P Zenner, E Glowatzki
Affiliations
Free article

Desensitization of the P2X(2) receptor controlled by alternative splicing

U Brändle et al. FEBS Lett. .
Free article

Abstract

P2X receptors are ion channels gated by extracellular ATP. We report here cloning of a P2X(2) receptor splice variant (P2X(2-2)) carrying a 207 bp deletion in the intracellular C-terminus and the analysis of the corresponding genomic structure of the P2X(2) gene. P2X(2-2) is as highly expressed as the original P2X(2) sequence in various tissues. ATP-activated currents mediated by heterologous expressed P2X(2) or P2X(2-2) receptors showed significant differences in desensitization time constants and steady-state currents in the continuous presence of ATP. These results imply functional differences between cells differentially expressing these P2X(2) isoforms.

PubMed Disclaimer

Publication types

MeSH terms

Associated data

LinkOut - more resources