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Clinical Trial
. 1996 Dec 27;70(2):179-83.
doi: 10.1016/s0301-2115(95)02603-7.

Intravenous albumin prevents moderate-severe ovarian hyperstimulation in in-vitro fertilization patients: a prospective, randomized and controlled study

A Z Isik  1 , O Gokmen, H B Zeyneloglu, S Kara, G Keles, B Gulekli
Affiliations
Clinical Trial

Intravenous albumin prevents moderate-severe ovarian hyperstimulation in in-vitro fertilization patients: a prospective, randomized and controlled study

A Z Isik et al. Eur J Obstet Gynecol Reprod Biol. .

Abstract

Objective: To assess the effectiveness of intravenous administration of albumin in prevention of ovarian hyperstimulation syndrome (OHSS) in patients of an in-vitro fertilization program.

Study design: Prospective randomized study. Patients with hCG day E2 levels are 11010 pmol/l (3000 pg/ml) or more were recruited into two groups. Group A (n = 27) received 10 g 20%, 50 ml human albumin infusion before oocyte pick-up and no medication was administered in Group B (n = 28).

Results: Patients were similar in terms of cycle characteristics. No moderate-severe OHSS developed in Group A whereas one severe OHSS case and four moderate OHSS cases developed in Group B. Statistical analysis revealed a significant (P < 0.05) protection in albumin treated group.

Conclusion: Human albumin proves effectiveness in prevention of moderate-severe OHSS.

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