Intravenous albumin prevents moderate-severe ovarian hyperstimulation in in-vitro fertilization patients: a prospective, randomized and controlled study
- PMID: 9119100
- DOI: 10.1016/s0301-2115(95)02603-7
Intravenous albumin prevents moderate-severe ovarian hyperstimulation in in-vitro fertilization patients: a prospective, randomized and controlled study
Abstract
Objective: To assess the effectiveness of intravenous administration of albumin in prevention of ovarian hyperstimulation syndrome (OHSS) in patients of an in-vitro fertilization program.
Study design: Prospective randomized study. Patients with hCG day E2 levels are 11010 pmol/l (3000 pg/ml) or more were recruited into two groups. Group A (n = 27) received 10 g 20%, 50 ml human albumin infusion before oocyte pick-up and no medication was administered in Group B (n = 28).
Results: Patients were similar in terms of cycle characteristics. No moderate-severe OHSS developed in Group A whereas one severe OHSS case and four moderate OHSS cases developed in Group B. Statistical analysis revealed a significant (P < 0.05) protection in albumin treated group.
Conclusion: Human albumin proves effectiveness in prevention of moderate-severe OHSS.
Similar articles
-
Intravenous albumin versus hydroxyethyl starch for the prevention of ovarian hyperstimulation in an in-vitro fertilization programme: a prospective randomized placebo controlled study.Eur J Obstet Gynecol Reprod Biol. 2001 Jun;96(2):187-92. doi: 10.1016/s0301-2115(00)00452-8. Eur J Obstet Gynecol Reprod Biol. 2001. PMID: 11384805 Clinical Trial.
-
Intravenous albumin does not prevent the development of severe ovarian hyperstimulation syndrome.Fertil Steril. 1997 Aug;68(2):287-91. doi: 10.1016/s0015-0282(97)81517-8. Fertil Steril. 1997. PMID: 9240258
-
Comparison of intravenous albumin and transfer of fresh embryos with cryopreservation of all embryos for subsequent transfer in prevention of ovarian hyperstimulation syndrome.Fertil Steril. 1996 May;65(5):992-6. doi: 10.1016/s0015-0282(16)58275-2. Fertil Steril. 1996. PMID: 8612863 Clinical Trial.
-
The prevention of ovarian hyperstimulation syndrome.J Obstet Gynaecol Can. 2014 Nov;36(11):1024-1033. doi: 10.1016/S1701-2163(15)30417-5. J Obstet Gynaecol Can. 2014. PMID: 25574681 Review. English, French.
-
Human albumin is effective in prevention of severe OHSS.Acta Obstet Gynecol Scand. 2001 Oct;80(10):878-82. doi: 10.1034/j.1600-0412.2001.801002.x. Acta Obstet Gynecol Scand. 2001. PMID: 11580730 Review.
Cited by
-
Embryo freezing for preventing ovarian hyperstimulation syndrome.Cochrane Database Syst Rev. 2007 Jul 18;2007(3):CD002806. doi: 10.1002/14651858.CD002806.pub2. Cochrane Database Syst Rev. 2007. PMID: 17636707 Free PMC article.
-
Evaluation of intravenous hydroxylethyl starch, intravenous albumin 20%, and oral cabergoline for prevention of ovarian hyperstimulation syndrome in patients undergoing ovulation induction.J Res Med Sci. 2015 Jul;20(7):692-6. doi: 10.4103/1735-1995.166228. J Res Med Sci. 2015. PMID: 26622260 Free PMC article.
-
Comparison of the Effectiveness of Various Medicines in the Prevention of Ovarian Hyperstimulation Syndrome: A Network Meta-Analysis of Randomized Controlled Trials.Front Endocrinol (Lausanne). 2022 Jan 26;13:808517. doi: 10.3389/fendo.2022.808517. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 35154015 Free PMC article.
-
Pharmacologic Interventions in Preventing Ovarian Hyperstimulation Syndrome: A Systematic Review and Network Meta-Analysis.Sci Rep. 2016 Jan 11;6:19093. doi: 10.1038/srep19093. Sci Rep. 2016. PMID: 26752241 Free PMC article.
-
Aggressive outpatient treatment of ovarian hyperstimulation syndrome with ascites using transvaginal culdocentesis and intravenous albumin minimizes hospitalization.J Assist Reprod Genet. 2002 Apr;19(4):159-63. doi: 10.1023/a:1014828027282. J Assist Reprod Genet. 2002. PMID: 12036082 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
