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. 1997 Apr;65(4):1557-60.
doi: 10.1128/iai.65.4.1557-1560.1997.

Purification and characterization of a Na+, K+ ATPase inhibitor found in an endotoxin of Leptospira interrogans

P Burth  1 , M Younes-Ibrahim, F H Gonçalez, E R Costa, M V Faria
Affiliations

Purification and characterization of a Na+, K+ ATPase inhibitor found in an endotoxin of Leptospira interrogans

P Burth et al. Infect Immun. 1997 Apr.

Abstract

We showed previously that the glycolipoprotein fraction prepared from Leptospira interrogans inhibited the Na+,K+ ATPase enzyme purified from brain or kidney and in isolated nephron segments (M. Younes-Ibrahim, P. Burth, M. V. Castro Faria, B. Buffin-Meyer, S. Marsy, C. Barlet-Bas, L. Cheval, and A. Doucet, C. R. Acad. Sci. Paris Ser. III 318:619-625, 1995). In the present communication, we have demonstrated that unsaturated fatty acids such as oleic and palmitoleic acids, which are adsorbed to this fraction, are effective inhibitors of the enzyme.

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