Neuropharmacological correction of cognitive processes disrupted by extirpation of the AI-AII and Ep fields in cats

Abstract

An original neuropsychophysiological battery of tests was used to study the possibility of neuropharmacological correction of compensatory-restorative processes in cats after extirpation of a defined zone of the temporal cortex; studies were carried out in conditions of free behavior. In a variety of activation and inhibition regimes, systemic administration of cholinergic, dopaminergic, GABAergic, and serotoninergic agents could have favorable effects on restorative mechanisms, depending on cortical psycho-organic symptoms. Each cognitive activity studied (perception, gnosis, thought) had its own specific positive neuromediator "profile" in terms of compensatory outcomes.