Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1977 Sep;61(1):97-100.
doi: 10.1111/j.1476-5381.1977.tb09745.x.

Comparative inhibitory effects of 3-quinuclidinyl benzilate (QNB) and atropine on amylase release from rat pancreas

J Morisett, K H Ng, G G Poirier
Comparative Study

Comparative inhibitory effects of 3-quinuclidinyl benzilate (QNB) and atropine on amylase release from rat pancreas

J Morisett et al. Br J Pharmacol. 1977 Sep.

Abstract

1 Secrection of amylase from rat pancreas stimualted by urecholine was studied in relation to its inhibition by atropine and 3-quinuclidinyl benzilate (QNB). 2 Urecholine-induced secretion was completely abolished by atropine at 10(-6)M and QNB at 10(-8)M. Significant inhibition could be detected at 10(-8)M atropine and 10(-10)M QNB. 3 The secretory response to pancreozymin was not blocked either by atropine or QNB. 4 The inhibitory effect of QNB remained for at least 90 min after its removal from the incubation medium. 5 It is concluded that QNB is 10 times more potent than atropine in inhibiting pancreatic amylase secretion induced by urecholine.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Methods Biochem Anal. 1954;1:287-305 - PubMed
    1. J Physiol. 1973 Jun;231(2):283-95 - PubMed
    1. J Physiol. 1973 Nov;234(3):689-701 - PubMed
    1. Can J Physiol Pharmacol. 1974 Apr;52(2):174-82 - PubMed
    1. Proc Natl Acad Sci U S A. 1974 May;71(5):1725-9 - PubMed

Publication types

LinkOut - more resources