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Review
. 1996;156(3):227-39.
doi: 10.1159/000147849.

Model systems of epithelium-mesenchyme transitions

B Boyer  1 , A M Vallés, J P Thiery
Affiliations
Review

Model systems of epithelium-mesenchyme transitions

B Boyer et al. Acta Anat (Basel). 1996.

Abstract

This contribution discusses which factors bring about the transformation of epithelium to mesenchyme. Amongst biological agents which have this role are a number of cytokines (e.g. EGF, FGF-1, TGF-beta, HGF/SF) and extracellular matrix macromolecules, such as collagens. The coordinated changes in cell morphology, associated with the induction of cell motility and the loss of inter-cellular junctions, are under the control of signaling molecules that transduce the signal emanating from the plasma membrane, which ultimately lead to changes in gene expression.

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