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. 1997 May;65(5):1953-5.
doi: 10.1128/iai.65.5.1953-1955.1997.

Arabinofuranosyl-terminated and mannosylated lipoarabinomannans from Mycobacterium tuberculosis induce different levels of interleukin-12 expression in murine macrophages

A Yoshida  1 , Y Koide
Affiliations

Arabinofuranosyl-terminated and mannosylated lipoarabinomannans from Mycobacterium tuberculosis induce different levels of interleukin-12 expression in murine macrophages

A Yoshida et al. Infect Immun. 1997 May.

Abstract

Lipoarabinomannan (LAM) is a major surface lipoglycan of Mycobacterium tuberculosis. In the present study, we demonstrated that arabinofuranosyl-terminated LAM (AraLAM) derived from a rapidly growing Mycobacterium sp., but not extensively mannosylated LAM derived from the Erdman strain, is capable of inducing interleukin-12 (IL-12) expression in murine macrophages. Since IL-12 is known to drive the differentiation of naive T cells toward T-helper type 1 (Th1) cell development, AraLAM may be an effective adjuvant in vaccines and immunotherapies that need Th1 responses.

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References

    1. J Biol Chem. 1986 Sep 15;261(26):12345-51 - PubMed
    1. Eur J Immunol. 1995 Mar;25(3):672-6 - PubMed
    1. J Immunol. 1992 Jan 1;148(1):92-8 - PubMed
    1. J Exp Med. 1992 Apr 1;175(4):1111-22 - PubMed
    1. J Biol Chem. 1992 Mar 25;267(9):6234-9 - PubMed

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