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Review
. 1997 Apr;40(2):143-5.

Aggressive giant condyloma acuminatum associated with oncogenic human papilloma virus: a case report

A Kibrité  1 , N C Zeitouni, R Cloutier
Affiliations
Review

Aggressive giant condyloma acuminatum associated with oncogenic human papilloma virus: a case report

A Kibrité et al. Can J Surg. 1997 Apr.

Abstract
in English, French

Malignant transformation has been described in 30% of cases of giant anorectal condyloma acuminatum. The authors report on a 33-year-old man who was heterosexual and HIV negative and who had a giant anal condyloma. Despite aggressive therapy with multiple fulgurations, interferon alpha and isotretinoin, an invasive squamous cell carcinoma of the rectum developed. An abdominoperineal resection was done followed by radiotherapy and chemotherapy, but this treatment regimen was unsuccessful in controlling the progression of his carcinoma. Human papillomavirus (HPV) serotyping in tumoral tissue was positive for HPV types 11 and 16. In patients with giant anorectal condylomas associated with oncogenic HPV, the course of the disease may be aggressive, so they may benefit from early surgical and medical intervention.

On a décrit une évolution maligne dans 30 % des cas de condylome acuminé ano-rectal. Les auteurs décrivent le cas d’un homme de 33 ans, hétérosexuel et non infecté par le VIH, qui avait un condylome anal géant. Malgré une thérapie agressive comportant de multiples fulgurations, l’administration d’interféron alpha et d’isotrétinoïne, un carcinome spinocellulaire invasif du rectum a fait son apparition. On a procédé à une ré-section abdominopérinéale suivie d’une radiothérapie et d’une chimiothérapie, mais ces traitements n’ont pas réussi à enrayer l’évolution du carcinome. Le sérotypage du papillomavirus humain (HPV) de tissus de la tumeur a donné des résultats positifs quant aux types 11 et 16 du HPV. Chez les patients atteints de condylomes ano-rectaux géants associés au HPV oncogène, l’évolution de la maladie peut être brutale et une intervention chirurgicale et médicale rapide peut donc être bénéfique pour les patients en cause.

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