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Review
. 1997 Jan;3(1):5-20.

The CDKN2A (p16) gene and human cancer

W D Foulkes  1 , T Y Flanders, P M Pollock, N K Hayward
Affiliations
Review

The CDKN2A (p16) gene and human cancer

W D Foulkes et al. Mol Med. 1997 Jan.

Abstract

CDKN2A, the gene encoding the cell-cycle inhibitor p16CDKN2A, was first identified in 1994. Since then, somatic mutations have been observed in many cancers and germline alterations have been found in kindreds with familial atypical multiple mole/melanoma (FAMMM), also known as atypical mole syndrome. In this review we tabulate the known mutations in this gene and discuss specific aspects, particularly with respect to germline mutations and cancer predisposition.

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References

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