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. 1977 Sep-Nov;2(5-6):495-500.
doi: 10.1016/0376-8716(77)90049-7.

Possible involvement of acetaldehyde, norepinephrine and their tetrahydroisoquinoline derivatives in the regulation of ethanol seld-administration

Z Amit, Z W Brown, G E Rockman

Possible involvement of acetaldehyde, norepinephrine and their tetrahydroisoquinoline derivatives in the regulation of ethanol seld-administration

Z Amit et al. Drug Alcohol Depend. 1977 Sep-Nov.

Abstract

In this study, we examined the possible role of acetaldehyde in the mediation of the reinforcing properties of ethanol. We also examined the possible interaction of acetaldehyde and brain norepinephrine in this mediation. We found that rats will self-administer acetaldehyde delivered into the cerebral ventricles, and that this operant behaviour can be attenuated by injections of a dopamine-beta-hydroxylase inhibitor. The results are discussed in terms of a role for tetrahydroisoquinoline alkaloids in alcoholism.

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