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. 1997 Apr 10;14(14):1753-7.
doi: 10.1038/sj.onc.1200986.

The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p

P Jay  1 , J L Bergé-Lefranc, C Marsollier, C Méjean, S Taviaux, P Berta
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The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p

P Jay et al. Oncogene. .

Abstract

Complementary DNA encoding the human CYR61 protein was isolated from human embryonic tissues and mapped to chromosome 1p22-p31. We show that CYR61 encodes a 381 amino acid protein rich in cysteine and proline residues that is strongly conserved with the mouse homologue. Sequence analysis reveals the presence of several distinct protein domains which confer a mosaic structure to this protein and makes human CYR61 a member of a recently described growth regulator family that includes several proto-oncogene products. From our results we hypothesize that this new immediate early gene may play a role in cell commitment during embryogenesis and more generally in the control of cell proliferation.

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