Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1977 Aug;13(4):367-71.
doi: 10.1007/BF01223280.

Plasma insulin and glucose levels in maturity onset diabetics treated with chlorpropamide

G M Shenfield, A Logan, D Shirling, J Baird

Plasma insulin and glucose levels in maturity onset diabetics treated with chlorpropamide

G M Shenfield et al. Diabetologia. 1977 Aug.

Abstract

19 diabetic patients taking various doses of chlorpropamide were studied throughout a normal day. Plasma chlorpropamide levels were related to the daily dose of the drug and were relatively constant throughout the day. Blood glucose concentration was highest and the plasma insulin concentration lowest in patients taking the largest dose of chlorpropamide. Patients on a small daily dose of chlorpropamide were well controlled and had higher than normal insulin levels. --12 patients were restudied 10 days after stopping chlorpropamide. Although diabetic control deteriorated in all patients, plasma insulin concentration did not change significantly. This suggests that the long-term hypoglycaemic action of chlorpropamide is not dependent on an effect on the concentration of insulin in peripheral venous blood.

PubMed Disclaimer

References

    1. Diabetologia. 1974 Feb;10(1):27-35 - PubMed
    1. Arch Intern Med. 1969 Mar;123(3):314-22 - PubMed
    1. J Lab Clin Med. 1961 Jun;57:970-80 - PubMed
    1. Ann Intern Med. 1968 Apr;68(4):757-69 - PubMed
    1. Ann N Y Acad Sci. 1959 Mar 30;74(3):1021-8 - PubMed