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Case Reports
. 1997;35(3):321-4.
doi: 10.3109/15563659709001220.

Fatal bupropion overdose

C R Harris  1 , J Gualtieri, G Stark
Affiliations
Case Reports

Fatal bupropion overdose

C R Harris et al. J Toxicol Clin Toxicol. 1997.

Abstract

Background: Bupropion is a unique monocyclic antidepressant that has been known to cause seizures in high therapeutic doses and in acute overdoses. Death due to ingestion, however, is a rare occurrence.

Case report: We report a case of a 26-year-old man who ingested 23 g bupropion, developed seizures and hypoxia, and presented in cardiac arrest. The patient was resuscitated in the emergency department, but died 4 d after supportive intensive care.

Conclusions: Bupropion overdose may lead to recurrent seizures, hypoxia and death. Aggressive management of severe bupropion overdose is recommended.

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