Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1997 May;82(5):1635-7.
doi: 10.1210/jcem.82.5.3928.

Dexamethasone increases leptin expression in humans in vivo

S Papaspyrou-Rao  1 , S H Schneider, R N Petersen, S K Fried
Affiliations

Dexamethasone increases leptin expression in humans in vivo

S Papaspyrou-Rao et al. J Clin Endocrinol Metab. 1997 May.

Abstract

The effect of 2 days of oral dexamethasone administration (0.75 mg twice daily) on leptin expression in healthy volunteers was tested. Dexamethasone increased the relative abundance of leptin messenger RNA in abdominal and gluteal adipose tissues by approximately 70% (P < 0.05). Dexamethasone also significantly increased serum leptin (+ 80%) and insulin concentration (+ 83%) but did not affect serum glucose. We conclude that a hypercortisolemic/hyperinsulinemic state up-regulates leptin expression at the messenger RNA level in humans.

PubMed Disclaimer

Comment in

Publication types

LinkOut - more resources