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Review
. 1997 May 13;94(10):4825-7.
doi: 10.1073/pnas.94.10.4825.

A massage for the journey: keeping leukocytes soft and silent

U H von Andrian
Review

A massage for the journey: keeping leukocytes soft and silent

U H von Andrian. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
Delayed entry of neutrophils into a rabbit mesentery capillary. (A) A schematic drawing depicts the microvascular anatomy; an arteriole (art) and a branched venule (ven) can be seen. The ostium of a capillary (cap) branching off the arteriole is indicated by an arrowhead. The direction of blood flow is indicated by arrows. (B) Intravital micrograph of fluorescently labeled neutrophils. Cells were visualized by stroboscopic epi-illumination, which causes the appearance of fast-moving fluorescent cells as bright spheres with several fainter after-images. One neutrophil (white arrowhead) has just become stuck in the capillary’s ostium. (C) The cell is visibly deformed 0.73 s after it has become stuck. Blood flow in the downstream capillary has come to a complete stop, whereas flow in the arteriole remains unobstructed. This is evident because several other neutrophils in the arteriole are passing the stuck cell without apparent delay. The neutrophil’s trailing end, which remains in the arteriolar lumen, is exposed to an estimated shear stress of 40 dynes/cm2. This fluid shear may confer a signal to the cell that may enhance its deformability so that it can eventually pass the capillary entrance. (D) After a period of 1.13 s since the neutrophil had initially stopped, it has deformed sufficiently to enter the capillary and continue its passage without further delay.
See this image and copyright information in PMC

Comment on

  • The leukocyte response to fluid stress.
    Moazzam F, DeLano FA, Zweifach BW, Schmid-Schönbein GW. Moazzam F, et al. Proc Natl Acad Sci U S A. 1997 May 13;94(10):5338-43. doi: 10.1073/pnas.94.10.5338. Proc Natl Acad Sci U S A. 1997. PMID: 9144238 Free PMC article.

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