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. 1997 Apr 17;233(2):336-42.
doi: 10.1006/bbrc.1997.6455.

A novel G protein-coupled receptor with homology to neuropeptide and chemoattractant receptors expressed during bone development

A Methner  1 , G Hermey, B Schinke, I Hermans-Borgmeyer
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A novel G protein-coupled receptor with homology to neuropeptide and chemoattractant receptors expressed during bone development

A Methner et al. Biochem Biophys Res Commun. .

Abstract

A novel G protein-coupled receptor was isolated from a cDNA derived from the cell line NH15-CA2 and a cDNA library from adult mouse brain using a PCR cloning strategy. The amino acid sequence of the candidate receptor DEZ showed homology to neuropeptide and chemoattractant receptors. Highest overall homology was found with the orphan receptor GPR-1 (65%), the angiotensin II receptor (62%), and the C5a anaphylatoxin receptor (60%). Northern blot analysis of dez revealed a predominant 2.6 kb mRNA species in NH15-CA2 cells. In situ hybridization experiments showed that dez is differentially regulated during development, with a prominent expression in developing osseous and cartilaginous tissue. It was also detectable in the adult parathyroid glands, hinting at a possible function in bone metabolism.

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