doi: 10.1248/cpb.45.675.
Inhibitory effects of quassinoid derivatives on Epstein-Barr virus early antigen activation
Affiliations
- PMID: 9145503
- DOI: 10.1248/cpb.45.675
Item in Clipboard
Inhibitory effects of quassinoid derivatives on Epstein-Barr virus early antigen activation
Chem Pharm Bull (Tokyo).
1997 Apr.
Abstract
Short-term in vitro assays for tumor promoters and antitumor promoters (Epstein-Barr virus activation test) were carried out for semisynthetic quassinoids (3-7), which were obtained by esterification of the C-15 OH group of deacetylated isobrucein-B (2). All the ester derivatives showed higher antitumor promoting activity than that of the potent compound 2. A compound containing a fluorinated aliphatic ester showed the highest potency.
Similar articles
-
Quassinoids as inhibitors of Epstein-Barr virus early antigen activation.Cancer Lett. 1997 Feb 26;113(1-2):165-8. doi: 10.1016/s0304-3835(97)04607-7. Cancer Lett. 1997. PMID: 9065817
-
Cytotoxic quassinoids from Cedronia granatensis.J Nat Prod. 1992 May;55(5):667-71. doi: 10.1021/np50083a018. J Nat Prod. 1992. PMID: 1517739
-
Synthesis of cytotoxic fluorinated quassinoids.Bioorg Med Chem. 1997 Aug;5(8):1489-95. doi: 10.1016/s0968-0896(97)00095-3. Bioorg Med Chem. 1997. PMID: 9313855
-
Quassinoid bitter principles. II.Fortschr Chem Org Naturst. 1985;47:221-64. doi: 10.1007/978-3-7091-8790-6_4. Fortschr Chem Org Naturst. 1985. PMID: 3896993 Review. No abstract available.
-
Relationship between Structural Characteristics and Plant Sources along with Pharmacology Research of Quassinoids.Chem Pharm Bull (Tokyo). 2019;67(7):654-665. doi: 10.1248/cpb.c18-00958. Chem Pharm Bull (Tokyo). 2019. PMID: 31257321 Review.
Cited by
-
Ailanthone: A novel potential drug for treating human cancer.Oncol Lett. 2020 Aug;20(2):1489-1503. doi: 10.3892/ol.2020.11710. Epub 2020 Jun 9. Oncol Lett. 2020. PMID: 32724391 Free PMC article. Review.
-
Antitumor activity of the Ailanthus altissima bark phytochemical ailanthone against breast cancer MCF-7 cells.Oncol Lett. 2018 Apr;15(4):6022-6028. doi: 10.3892/ol.2018.8039. Epub 2018 Feb 13. Oncol Lett. 2018. PMID: 29552229 Free PMC article.