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. 1997 May;41(5):1134-6.
doi: 10.1128/AAC.41.5.1134.

Emergence of the trimethoprim resistance gene dfrD in Listeria monocytogenes BM4293

E Charpentier  1 , P Courvalin
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Emergence of the trimethoprim resistance gene dfrD in Listeria monocytogenes BM4293

E Charpentier et al. Antimicrob Agents Chemother. 1997 May.

Abstract

The sequence of the trimethoprim resistance gene of the 3.7-kb plasmid (pIP823) that confers high-level resistance (MIC, 1,024 microg/ml) to Listeria monocytogenes BM4293 was determined. The gene was identical to dfrD recently detected in Staphylococcus haemolyticus MUR313. The corresponding protein, S2DHFR, represents the second class of high-level trimethoprim-resistant dihydrofolate reductase identified in gram-positive bacteria. We propose that trimethoprim resistance in L. monocytogenes BM4293 could originate in staphylococci.

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