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Case Reports
. 1997 May;36(5 Pt 2):815-8.
doi: 10.1016/s0190-9622(97)70029-x.

Methotrexate-induced toxic epidermal necrolysis in a patient with psoriasis

E J Primka 3rd  1 , C Camisa
Affiliations
Case Reports

Methotrexate-induced toxic epidermal necrolysis in a patient with psoriasis

E J Primka 3rd et al. J Am Acad Dermatol. 1997 May.

Abstract

We describe a fatal case of low-dose methotrexate (MTX) toxicity in a patient with psoriasis, emphasizing the factors that exacerbate MTX toxicity and presenting rescue techniques. The patient had a toxic epidermal necrolysis-like condition. MTX cutaneous reactions ranging from toxic epidermal necrolysis to specific ulcerations have been described. The use of granulocyte colony stimulating factor for leukopenia associated with MTX toxicity is discussed.

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