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. 1997 Jun;157(6):2179-82.

Biological variation of total, free and percent free serum prostate specific antigen levels in screening volunteers

D K Ornstein  1 , D S Smith, G S Rao, J W Basler, T L Ratliff, W J Catalona
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  • PMID: 9146610

Biological variation of total, free and percent free serum prostate specific antigen levels in screening volunteers

D K Ornstein et al. J Urol. 1997 Jun.

Abstract

Purpose: We determined the biological variation of the total, free and percent free serum prostate specific antigen (PSA) in men 50 years old or older.

Materials and methods: Between July 1995 and February 1996 we studied 84 healthy men from our PSA screening study to determine biological variation by calculating the coefficients of variation of 3 PSA measurements on blood samples drawn from each subject 2 weeks apart.

Results: The mean coefficients of variation for total, free and percent free serum PSA were 15, 17 and 14%, respectively. Age, total PSA and ejaculation were not confounding factors in this analysis (that is multivariate R2 less than 5% for all indexes).

Conclusions: There is a mean variation of approximately 15% in measurements of total, free and percent free PSA that does not appear to be significantly affected by age and total PSA level.

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Comment in

  • Prostate specific antigen.
    Benson MC. Benson MC. J Urol. 1997 Jun;157(6):2197-8. doi: 10.1016/s0022-5347(01)64715-3. J Urol. 1997. PMID: 9146613 No abstract available.

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