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. 1997 Mar-Apr;30(2):125-8.
doi: 10.1590/s0037-86821997000200007.

[Treatment of the mucosal form of leishmaniasis without response to glucantime, with liposomal amphotericin B]

[Article in Portuguese]
R N Sampaio  1 , P D Marsden
Affiliations

[Treatment of the mucosal form of leishmaniasis without response to glucantime, with liposomal amphotericin B]

[Article in Portuguese]
R N Sampaio et al. Rev Soc Bras Med Trop. 1997 Mar-Apr.

Abstract

We treated six patients with mucosal leishmaniasis who failed to respond to glucantime (20 mg/kg/day) with ambisome (2-5 grams total dose). The daily dose was 2-3 mg/kg/day given for a minimum of 20 days. After 26-38 months of follow up, five patients were clinically cured. One relapsed after six months. No side effects of therapy were observed apart from headache after infection. Ambisome is a therapeutic option for patients with mucosal leishmaniasis unresponsive to antimonials.

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