[Spectrographic studies on the radioresistance of Miltex and miltefosine]

Abstract

Aim: With simultaneous application of Miltex and radiation therapy in the combined treatment of topical relapses and skin metastases in breast carcinoma patients the question arises, how radioresistant is the new cytotoxic agent. Because of the long penetration times of the active agent miltefosine the answer is important with particular regard to the time of the external application of Miltex.

Material and method: After the application of a single dose of 10 Gy we studied the stability of the commercial preparation and its active agent miltefosine by means of absorption spectroscopy.

Results: Immediately following the irradiation no alterations in absorption spectra of Miltex and miltefosine were found. However, 2 and 8 h post radiation the absorption curves of Miltex and miltefosine solutions were distinctly changed. The radiation induced changes of Miltex dilutions were smaller than those of the miltefosine solutions. For the commercial preparation the amount of the radiation-induced destruction is 0.10.

Conclusions: Consequently Miltex has shown a sufficient radioresistance or its decrease in the effectiveness is small. With daily single doses of 2 Gy in the radiotherapy of the topical relapses and skin metastases the destruction degree should be reduced to 0.02 assuming linear changes. Because of the distinct changes in the spectra and relative slow penetration of miltefosine in various cell lines [10, 11, 14] we will propose an application of the commercial cytotoxic agent 5 h before the radiation fractions. The smaller effect on Miltex is discussed in relation to the solution mediators of the active agent.