Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 1997 Mar;181(3):253-4.
doi: 10.1002/(SICI)1096-9896(199703)181:3<253::AID-PATH755>3.0.CO;2-0.

Do HPV-negative cervical carcinomas exist?

J M Walboomers, C J Meijer
Editorial

Do HPV-negative cervical carcinomas exist?

J M Walboomers et al. J Pathol. 1997 Mar.

Abstract

Based on improvements in HPV detection technology, it appears that an almost 100% HPV association is reached for cervical cancer, as demonstrated in an accompanying paper in this issue of the Journal. Factors which may explain the rare cases in which no HPV DNA is detectable include: improper sampling; disruption of HPV by integration events; the existence of still unidentified HPVs; sensitivity of the method; and the mechanism of transformation. Finally, epidemiological studies identifying HPV independent risk factors are necessary to answer the question of whether HPV independent pathways exist for cervical carcinogenesis.

PubMed Disclaimer

Publication types