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Clinical Trial
. 1996 Apr;32(2):177-82.
doi: 10.1111/j.1440-1754.1996.tb00918.x.

Haemodynamic effects of differing blood transfusion rates in infants less than 1500 g

Y Nosè  1 , H Tamai, S Shimada, M Funato
Affiliations
Clinical Trial

Haemodynamic effects of differing blood transfusion rates in infants less than 1500 g

Y Nosè et al. J Paediatr Child Health. 1996 Apr.

Abstract

Objective: To investigate whether the haemodynamic effects of the standard 2-3 h blood transfusion increases the risk for intraventricular haemorrhage (IVH) and patent ductus arteriosus (PDA) in very low birthweight infants.

Methodology: In a randomized controlled study, haemodynamic changes using slow and rapid transfusion were compared. Twenty-seven very low birthweight infants were divided between 12h (n = 14) and 3h (n = 13) transfusion groups. Blood pressure, ejection fraction (EF), anterior cerebral artery pulsatility index (PI), blood gases, serum electrolytes and haematocrit were measured pre- and post-transfusion. Infectious status was also monitored.

Results: Blood pressure (48.1/25.5 vs 55.7/30.2 mmHg) and EF (0.68 vs 0.73) increased significantly during rapid transfusion (P<0.01) but remained stable with slow transfusion. Serum potassium, base excess and incidence of infection did not increase in either group.

Conclusions: Slow transfusion causes less haemodynamic disturbance than rapid transfusion, thereby preventing the potential risk for IVH and PDA.

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