Review
doi: 10.1016/s0955-0674(97)80002-6.
RNA polymerase II holoenzyme and transcriptional regulation
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- PMID: 9159076
- DOI: 10.1016/s0955-0674(97)80002-6
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Review
RNA polymerase II holoenzyme and transcriptional regulation
Curr Opin Cell Biol.
1997 Jun.
Abstract
RNA polymerase II holoenzymes isolated from yeast and mammalian cells are large, preassembled complexes that contain some or all of the general transcription initiation factors and many other polypeptides. Recent experiments suggest that these holoenzymes may mediate alterations in chromatin structure and play a key role in regulatory mechanisms that influence transcriptional initiation, RNA chain elongation, RNA processing and transcription termination.
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