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. 1997 Mar;55(3):145-9.
doi: 10.1016/s0165-2478(97)02696-5.

Characterization of an HIV-1 p24gag epitope recognized by a CD8+ cytotoxic T-cell clone

F Buseyne  1 , S Stevanovic, H G Rammensee, Y Rivière
Affiliations

Characterization of an HIV-1 p24gag epitope recognized by a CD8+ cytotoxic T-cell clone

F Buseyne et al. Immunol Lett. 1997 Mar.

Erratum in

  • Immunol Lett 2001 Aug 1;78(1):55

Abstract

A CD8+ cytotoxic T-cell clone that recognized HIV p24gag was isolated from an infected individual. The minimal epitope was localized to amino acids 308-316 (QASQEVKNW). Using allogeneic target cells, we found that lysis was restricted by the HLA-Cw0401 molecule. We observed that C1R cells, that express the HLA-Cw0401 allele are able to present the peptide to the cytotoxic clone, but with reduced efficiency. Other B-cell lines, that have been genotyped as HLA-Cw0401+ were unable to present the peptide to the clone, suggesting the existence of other variants of HLA-Cw0401 or a loss of cell surface expression of this molecule.

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