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. 1997 Jun;65(6):2483-7.
doi: 10.1128/iai.65.6.2483-2487.1997.

Modulation of neutrophil superoxide response and intracellular diacylglyceride levels by the bacterial pigment pyocyanin

M Muller  1 , T C Sorrell
Affiliations

Modulation of neutrophil superoxide response and intracellular diacylglyceride levels by the bacterial pigment pyocyanin

M Muller et al. Infect Immun. 1997 Jun.

Abstract

Low concentrations of pyocyanin are reported to enhance superoxide production by human neutrophils exposed to various stimuli, yet the mechanism remains unknown. Using lucigenin-enhanced chemiluminescence, we examined the kinetics of the neutrophil superoxide response in the presence of pyocyanin. At all concentrations (12.5 to 200 microM), pyocyanin decreased the peak superoxide response while prolonging the duration of the response. The prolonged response may be associated with an observed increase in intracellular diacylglyceride levels due to pyocyanin exposure.

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References

    1. J Infect Dis. 1990 Jul;162(1):178-85 - PubMed
    1. Infect Immun. 1989 Sep;57(9):2591-6 - PubMed
    1. Free Radic Biol Med. 1991;10(5):305-13 - PubMed
    1. Infect Immun. 1991 Sep;59(9):3316-8 - PubMed
    1. Arch Biochem Biophys. 1991 Mar;285(2):325-30 - PubMed

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