doi: 10.1128/jb.179.11.3786-3789.1997.
Membrane topology of the metal-tetracycline/H+ antiporter TetA(K) from Staphylococcus aureus
Affiliations
- PMID: 9171431
- PMCID: PMC179179
- DOI: 10.1128/jb.179.11.3786-3789.1997
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Membrane topology of the metal-tetracycline/H+ antiporter TetA(K) from Staphylococcus aureus
J Bacteriol.
1997 Jun.
Abstract
A series of fusions to the reporter proteins alkaline phosphatase and beta-galactosidase have been constructed in the predicted periplasmic and cytoplasmic loops of TetA(K), a protein responsible for efflux-mediated tetracycline resistance in Staphylococcus aureus. The results support a topological model of 14 transmembrane segments for TetA(K).
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