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. 1997 Jun;179(11):3786-9.
doi: 10.1128/jb.179.11.3786-3789.1997.

Membrane topology of the metal-tetracycline/H+ antiporter TetA(K) from Staphylococcus aureus

S L Ginn  1 , M H Brown, R A Skurray
Affiliations

Membrane topology of the metal-tetracycline/H+ antiporter TetA(K) from Staphylococcus aureus

S L Ginn et al. J Bacteriol. 1997 Jun.

Abstract

A series of fusions to the reporter proteins alkaline phosphatase and beta-galactosidase have been constructed in the predicted periplasmic and cytoplasmic loops of TetA(K), a protein responsible for efflux-mediated tetracycline resistance in Staphylococcus aureus. The results support a topological model of 14 transmembrane segments for TetA(K).

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